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Apart from NF-B, miR-146a attenuates inflammation in HG-treated primary human retinal microvascular endothelial cells (hRMECs) by inhibition of MyD88/TLR4 signaling and suppression of TNF- production, positioning it as a pivotal regulator of retinal endothelial dysfunction (77)

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250,251 At the same time, ethanol can directly affect the activities of MAT, BHMT, and other enzymes, interfere with Met metabolism, inhibit GSH formation, and weaken the antioxidant capacity of cells

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